For FEV1/FVC, genome-wide significant associations were seen for 119 SNPs at seven loci (Supplementary Table 2). The SNP with the smallest P value, rs1980057 (P=4.90×10−11), is located on chromosome 4q31.22, 81 kb away from the 5’-end of HHIP. There were 27 other genome-wide significant SNPs in the HHIP region (Fig. 2a). Additionally, 69 genome-wide significant SNPs were located in or near the 3’-end of GPR126 on chromosome 6q24.1, with the top SNP (rs3817928) having P=2.60×10−10 (Fig. 2b). Fifty-nine of these 69 GPR126 SNPs were associated with FEV1/FVC at genome-wide significance among never smokers (Supplementary Table 2). Seven chromosome 5q33.3 SNPs located in ADAM19 (Fig. 2c), two correlated chromosome 6p21.32 SNPs (r2=0.66, Fig. 2d) located in two genes (AGER and PPT2), four chromosome 4q22.1 SNPs near the 5’-end of FAM13A (Fig. 2e), two chromosome 9q22.32 SNPs in PTCH1 (Fig. 2f), and six chromosome 2q36.3 SNPs near the 3’-end of PID1 (Fig. 2g) were also significantly associated with FEV1/FVC in all participants. SNPs in AGER, PPT2, PTCH1, and PID1 had minor allele frequencies (MAFs) between 4 and 10%, while all other significantly
