Comparisons of gene coexpression modules identified in CTX, CN and CB yielded a somewhat unexpected result: many modules showed significant preservation of gene coexpression relationships across brain regions (Fig. 2 and Supplementary Table 2). Indeed, comparisons between CTX and CN indicated that seven modules showed > 50% overlap (P = 4.0 × 10−18 (high) to P = 4.9 × 10−155 (low)), whereas comparisons between CTX and CB indicated that eight modules showed > 50% overlap (P = 6.6 × 10−18 (high) to P = 1.4 × 10−123 (low)) (Fig. 2). Among modules with the most substantial overlap across networks, six were identified in all networks (M4, M9, M15, M16, M18 and M19), five in three networks (M1, M5, M8, M10 and M11) and six in two networks (M6, M7, M12, M13, M14 and M17) (Fig. 2 and Supplementary Table 2). In total, 61 out of 81 (77%) of the gene coexpression modules identified in this analysis revealed significant overlap with at least one other module from one other network (Supplementary Table 2).
