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Chunk #32 — Discussion

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Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults.
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sclerosis and ulcerative colitis) are located in potential regulatory DNA regions (ENCODE Project Consortium, 2012). Whether this is the case for common psychiatric disorders, such as the externalizing disorders examined here, remains to be seen. Moving beyond gene identification to identify how sets of genetic variants are implicated in gene regulation will provide critical insights into the biological processes underlying pathways to complex behavioral outcomes.