CRF2Rs have a more restricted distribution than the CRF1 subtype, and are primarily localized to the dorsal raphe nucleus, lateral septum, bed nucleus of the stria terminalis (BNST), amygdala, and hypothalamus, structures involved in behavioral stress responses (Cavalcante et al., 2006; Chalmers et al., 1995; Chen et al, 2011; Kuperman et al., 2010; Li et al., 2002; Van Pett et al., 2000). Some CRF2 receptor-expressing regions receive innervation from multiple sites containing different CRF/Ucn ligands, and studies using pharmacological tools may therefore be insufficient to identify the functional role of the respective endogenous input.
