Favorable effects have already been described in observational clinical studies, which demonstrated the efficacy of cilostazol in patients with MCI (Taguchi et al., 2013), donepezil-treated patients with clinically probable AD (Arai and Takahashi, 2009; Ihara et al., 2014), and AD with CVD (Sakurai et al., 2013). Randomized placebo-controlled clinical trials are being planned for patients with MCI.
