These approaches require substantial and integrated efforts, involving consortia such as the PGC, other academic groups, and industry in pre-competitive framework to drive forward target identification and qualification to the point where confidence will be high enough to begin a clinical validation process; sharing of data and expertise will be essential. It will only be through collaborative work that the field will muster enough breadth of data and resources for this effort to fulfill its translational potential beyond polygenic risk score and prediction, to the identification of new biology and eventually towards resolving the current blockages in psychiatric drug discovery.
