to identify the putatively causal variant. Another caveat is the apparent behavioral disinhibition and stress sensitivity observed in mice with reduced Ank3 expression(Leussis et al., 2012a), which motivated this study, requires further characterization at the level of behavior and neural circuits to better delineate the phenotype and connect it to human psychiatric behaviors. It will also be important to investigate the association between ANK3 and behavioral disinhibition in bipolar disorder and schizophrenia, which has not yet been addressed. Other study limitations include the modest size of the cohort and absence of a replication sample.
