such as examining aggregate genetic risk scores (e.g., Derringer et al., 2010; Karlson et al., 2010) or examining combinatorial genetic profiles that have known systemic effects (e.g., contrasting individuals who are positive and negative for a panel of risk or hypofunction variants). Fundamentally, although the findings to date are promising, it is important to recognize that the endophenotype approach is not the only possible framework for understanding genetic influences on discounting and the multiplicity of influences and mechanisms are worthy of consideration.
