In conclusion, our results demonstrate that BDNF in the mPFC is involved in CUS-induced depression-related behavior and increased stress susceptibility in postpartum female mice and postpartum-specific BDNF deletion revealed an important regulatory role of BDNF in depression-related behavior. FoxO1 may participate in the functional regulation of BDNF in this process. Our observations provide a basis for a novel neurobiological mechanism for the pathology and treatment of PPD.
