= 9.5, 50.0% replicate), however, these rates never approached those observed for cis-eQTLs. It is plausible that surrogate variable correction may mask true ‘master’ regulator effects, but as for cis-effects we identified more trans-eQTLs with surrogate variable correction than without and these associations were more likely to replicate (data not shown). While it is perhaps surprising that even extremely significant trans effects frequently fail to replicate, we note that this behavior is, to a certain extent, to be expected [27].
