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Chunk #63 — Methods — PrediXcan

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Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
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The resulting imputed, harmonized association summary statistics were then used as input to MetaXcan. The number of genes tested for each tissue is found in Supplementary Table 14. FDR correction was applied to account for the number of genes tested across all tissues (156,215 total tests). A gene’s predicted expression was considered significantly associated with OA if its FDR-adjusted p-value fell below a threshold of 0.05.