the same region.32 Similarly, despite our large sample size, power limitations still play a role for detecting additional associations with smaller effect sizes and/or arising from rarer variants. Finally, given the different levels of data availability and the difficulties for standardization across studies, we did not evaluate the effect of additional risk factors for osteoporosis, such as menopausal status and smoking, which can influence the genetic associations with BMD. Nonetheless, despite these limitations we have identified many novel and previously unsuspected associations with BMD variation and fracture risk.
