determine where indirect relationships link psychiatric and substance dependence disorders with cocaine dependence severity (e.g., using structural equation modeling). For example, dependence on substances (e.g., alcohol, cannabis, opioids) that are often used to self-medicate PTSD-related anxiety (Tarrier and Sommerfield, 2003) could mediate a relationship between PTSD and cocaine dependence severity that was not detected in the present study’s multivariate regression models.
