Chunk #71 — ONLINE METHODS: — Phenotype definitions, GWAS, quality control, and meta-analysis

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

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Supplementary Tables 3, 6, 7, and 27 report the lead SNPs, the loci, the results of the COJO analyses, and the results of a lookup of the lead SNPs in the NHGRI-EBI GWAS Catalog database20 for our seven main GWAS; Supplementary Fig. 12 shows the GWAS estimates of general-risk-tolerance lead SNPs in the 23andMe and UKB cohorts and in the replication GWAS, and Supplementary Data 1 shows LocusZoom plots for all the loci identified in the seven GWAS.