Oscillatory responses associated with response inhibition were investigated using a Go/NoGo paradigm in abstinent alcoholics (Kamarajan et al., 2004). Decreased power in delta and theta oscillations was observed in alcoholics, particularly during NoGo processing, and prominent frontally. These changes were confirmed in another study that reported reduced delta oscillations for No-Go, which was correlated with white-matter degradation in the cingulate bundles (Colrain et al., 2011). Offspring of alcoholics showed significantly decreased activity in delta (1–3 Hz), theta (4–7 Hz), and alpha1 (8–9 Hz) bands during the NoGo condition, as well as reduced delta and theta activity during the Go condition (Kamarajan et al., 2006). Similar to alcoholics, differences were more prominent in the NoGo than in the Go condition. Thus it seems probable that these oscillatory responses may antecede the development of AUDs.
