We prioritized 69 SNPs for replication in stage 2 based on the results from the three-study stage 1 meta-analysis, using a set of criteria we developed as part of a heuristic approach to the prioritization of loci for follow-up (Supplementary Methods). Briefly, we considered SNPs with a meta-analysis p value <10−4 and a meta-analysis heterogeneity p value >10−4. These selections were largely made using the initial OR-based version of the meta-analysis. We allowed some exceptions to the above follow-up criteria.
