Chunk #2 — Introduction

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Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.

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al., 1998; Yu et al., 2010). The most intensively investigated mouse is the Ts65Dn model, whose creation 26 years ago was instrumental in advancing this field of study (Davisson et al., 1990). Ts65Dn mice exhibit many phenotypes characteristic of DS including deficient cognition (Braudeau et al., 2011; Busciglio et al., 2013; Costa, 2011; Demas et al., 1998; Faizi et al., 2011; Fernandez et al., 2007; Gutierrez-Castellanos et al., 2013; Martinez-Cue et al., 2014; Smith et al., 2014).