LD, have been previously associated with other substance use traits, including smoking [54–56] and alcohol consumption [56], schizophrenia [57], education attainment and math ability [58], but the mechanism whereby this SNP affects OUD liability is largely unknown. Lastly, the gene-set analyses revealed that the polygenic signal for POU is implicated in pathways that modulate µ‐opioid receptor sensitization. Taken together, these findings suggest a potential avenue for identifying new therapeutic targets for problematic opioid use.
