Chunk #14 — Methods — Sedative and Ataxic Effects of Acute Administration — Locomotor activity

Source

Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration.

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After 20 minute habituation sessions to the locomotor runways for 2 days, WT and KO mice (n = 8) were injected i.p. with 0, 1, 2 or 3 g/kg and immediately placed in circular runways to record locomotor activity for 5 minutes. Ethanol doses were administered in a counterbalanced design, at 2 day intervals.