of autism. The mutation produced differential expression of thousands of genes enriched in GO functions such as β-catenin/Wnt signaling in mutated neurons, demonstrating the combined power of genome engineering and hiPSCs 151. This literature is still emerging, and it will be interesting to see whether a few common pathophysiological mechanisms underlying autism will emerge from these studies. In this respect, it will be essential to take into consideration technical and experimental variables that may influence the results.
