Functional imaging studies comparing activation in both adult and adolescent chronic cannabis users with healthy controls during the performance of different cognitive tasks indicated that chronic cannabis users would use similar brain areas that engage these cognitive processes but often demonstrating an altered pattern of brain activity [151], [152], [157], [165]–[177], [179], [181]–[183]. However, the level of performance of the cannabis users on the cognitive tasks employed was generally similar to that of controls [164], [165], [168], [171], [174], [177], or at least within what may be considered a normal range of test performance. Therefore, these findings may be interpreted as reflecting neuroadaptation, perhaps indicating the recruitment of additional regions as a compensatory mechanism to maintain normal cognitive performance in response to chronic cannabis exposure [151], [152], [164], [166], [171], [172], [175], [179]–[181], [183], particularly within the prefrontal cortex area [151], [166], [168], [169], [171], [181], [183]. In this regard, the brain seems able to achieve some degree of reorganization, activating brain regions not usually needed to perform the cognitive task in response to an impaired ability of the normally
