Chunk #5 — Methods — Literature search

Source

Lack of association between the A118G polymorphism of the mu opioid receptor gene (OPRM1) and opioid dependence: A meta-analysis.

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A systematic, computerized search of the current literature up to September 2008 was conducted using the PubMed©, Scopus, and Web of Science® online databases. Keywords used to identify articles examining the association between the A118G polymorphism and the occurrence of opioid dependence were Asn40Asp, A118G, opioid, opiate, heroin, dependence, addiction, mu-receptor polymorphism, OPRM1, and all the possible combinations thereof. The reference lists of identified studies as well as relevant reviews were also examined in an attempt to identify additional publications. Finally, the two existing meta-analyses were consulted5,9 and unpublished data from our laboratory was included.