During the last 5 years, a number of compounds have been reported to inhibit NF-κB by inhibiting acetylation. Gallic acid obtained from natural products such as gallnuts, sumac, oak bark, and green tea was recently reported to possess anti-histone acetyltransferase activity, thus showing potential to downregulate NF-κB activation [115]. Daxx, a protein associated with the death domain of Fas receptor, has been reported to suppress NF-κB transcriptional activity by inhibiting p300/CBP-mediated p65 acetylation [116]. Anacardic acid derived from traditional medicinal plants can also inhibit NF-κB activation by inhibiting p65 acetylation [117].
