allele and genotype frequency (Figures 1, 2, 4, 6). As India is not part of mainland Asia, its inhabitants have a different ancestral and hence genetic background and thus it may not be a valid inclusion. However, it should be noted that the impact of this study on the pooled Asian OR was relatively low in comparison to the other studies included (weights of 7.6% for allele data and 9.9% for genotype data), hence the inclusion in this grouping is not predicted to alter the overall ability to observe an association.
