Both parenchymal and vascular deposits of amyloid are typical of AD. There are, however, mutations in APP that do not produce substantial parenchymal deposition in the form of plaques but result in extensive vascular deposits. These mutations, rather than producing FAD, cause a hereditary form of recurrent intracerebral hemorrhage. One such mutation, E693Q, is known as the Dutch mutation. Interestingly, although most FAD mutations in APP reside near the β- and γ-secretase cleavage sites, mutations associated with cerebral hemorrhage such as the Dutch mutation tend to be found within the Aβ domain itself.
