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Chunk #28 — Results — Searches for chromosomal regions identified by clustered SNPs with nominally-significant case vs control differences in both African-American samples

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Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence.
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One hundred twenty nine chromosomal regions were identified by clustered nominally-positive results from both of the two African-American samples. None of 10,000 Monte Carlo simulation trials that each began with random sets of SNPs selected from each of the datasets identified as many overlapping regions as found in the true dataset; hence Monte Carlo p<0.0001. Thus, the null hypothesis that the chromosomal regions identified by both African American samples are found based only on stochastic grounds is nullified by these Monte Carlo data.