is seen for the dopamine-cAMP pathway. Cocaine functionally upregulates cAMP signaling in NAc (Carlezon et al., 2005), but simultaneously increases histone acetylation on the genes for the Gi-coupled D3 receptor and an inhibitor of Gi-signaling, RGS9. The NFκB and cAMP pathways exemplify the intricate cocaine-induced regulation of intracellular signaling in the NAc, and thereby underscore the importance of genome-wide studies which permit the parallel assessment of multiple molecular components of each pathway.
