Sensitivity analyses with parameters estimated from the same GLMM model fit with PHAD in place of PRS are summarized in Table 5 and depicted in Figure 2. At 21, consistent with the results from the model with the PRS, we found a significant positive interaction between PHAD and marital status, indicating that PHAD was associated with higher HED among married participants. Although the three-way interaction between age, PHAD, and marital status was not statistically significant, the direction of the negative three-way interaction was consistent with the result from the model using the PRS, indicating that the initial difference of the association between PHAD and HED by marital status was attenuated with age.
