We re-analyzed publicly available data from a microarray experiment (GEO accession No. GSE7762) designed to test the effects of different morphine treatments on gene expression in mouse striatum tissue. By comparison with control and chronic morphine treatment, we found that the expression of mouse Rgma was significantly decreased (all ANOVA P-values<0.01) after acute morphine challenge in all 4 mouse strains, except for C57BL/6J. Compared to acute morphine challenge, significant upregulation of Rgma was found in C57BL/6J mouse striatum after chronic morphine injection (ANOVA P-value<0.01). These results demonstrate that Rgma was differentially regulated in mouse striatum when comparing C57BL/6J with other mouse strains.
