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Chunk #74 — 4. Additional considerations of empirical relevance — 4.3. Limitations of the surface Laplacian: Caveats and empirical implications

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Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions.
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Computationally, the Laplacian suppresses volume-conducted contributions by eliminating the potential accounted for by the recording reference, as well as associated linear spatial trends. Because of this property, an active generator in surface cortex could also be strongly attenuated if it is broadly-distributed (e.g., diffusely synchronized). Likewise, the generators of EEG activity that is transmitted via local wave-propagation across contiguous cortical regions will also be difficult to identify using simple CSD methods if they result in traveling or standing waves (Robinson, 2003; Nunez and Srinivasan, 2006b).