Our primary hypotheses concerned the a priori ROIs of medial (mPFC) and ventromedial prefrontal cortex (vmPFC). These regions were sensitive to the [AO > ApCO] effect, with the right mPFC's [AO > ApCO] response discriminating between groups varying in a family history of alcoholism (Kareken, et al., 2010). Left and right medial frontal ROIs were those used in Kareken et al (2010), and have stereotactic boundaries that approximate the medial prefrontal regions to which the VTA and ventral striatum project (Chiba et al., 2001; Haber et al., 2006; Williams & Goldman-Rakic, 1998). These ROIs encompass activation from reward-associated stimuli in multiple studies (Filbey et al., 2008; Hare et al., 2008; Kable & Glimcher, 2007; McClure et al., 2007; Myrick et al., 2008; Schott et al., 2008), including a prior study by our group using a different sample (Bragulat et al., 2008). The ROIs defining the medial prefrontal areas have rostro-caudal extents spanning +56 mm to +36 mm in MNI space. mPFC has a superior extent of +14 mm and an inferior extent of −6 mm, while vmPFC spans −6 mm
