We analyzed one primary phenotype, DSM-IV alcohol dependence, and have performed secondary analyses using two phenotypes that included as affected only those meeting criteria for early onset DSM-IV alcohol dependence or those meeting the broader phenotype of alcohol dependence by COGA criteria. These alcohol dependence phenotypes are largely nested; they are not independent phenotypes, and some of the same SNPs affect risk for more than one of them. There is consistency in the patterns of association among the SNPs in LD with each other.
