In this GWA of large, rare CNVs in OCD and TS, although there was no global increase in CNV burden, we did find suggestive evidence for an increased burden of known, pathogenic neurodevelopmental deletions in patients with OCD/TS compared to controls. The 3.3-fold increased risk associated with this finding only reached trend-level significance, potentially due to the conservative bias toward the null introduced by having the majority of controls genotyped on a more sensitive, higher-density genotyping array than patients.
