Interestingly, among individuals diagnosed with CUD, BD comorbidity is lower but still substantial. A meta-analysis found an approximately 10% prevalence rate of BD in individuals with CUD in both community and clinical samples [5,6]. BD-I (8.8–9.0%) is more prevalent than BD-II (0.8–1.5%) in individuals with CUD [13]. Although less common than in CUD, BD is also more common in cannabis users without CUD compared to the general population (2.5%) [14]. In a more recent review and meta-analysis in subjects with cannabis use, the bipolar disorder rate was 9.6 % as indicated by Wave 2 results of the National Epidemiologic Survey on Alcohol and Related Conditions [15].
