The PGC is the largest and most systematic genomics effort in the history of psychiatry. In the next five years, we propose to markedly up-scale our work. By tackling nature as it is and not as we might want it to be, we hope to provide considerable new knowledge about the fundamental basis of psychiatric disorders. Our long-standing commitment to global collaboration, open science, and rapid progress means that we will make our results and tools available in a timely manner. Prediction of the future is always hazardous but, given that we finally have a minimally adequate toolkit for genomics, it is possible that we are entering a golden age of research into the fundamental basis of severe mental illness.