All work was performed in accordance with, and approved by, the Indiana University School of Medicine IACUC. Mice were offspring of HAP1, HAP2, LAP2, and HS/Ibg breeders, and were all born in the Indianapolis Veterans Administration Animal Care Facility. HS/Ibg breeders were supplied from the founding colony in Boulder, CO, and HS/Ibg mice used in this study were no more than 3 generations removed from those original breeders. Mice were all individually housed in polycarbonate cages (27.9 × 9.5 × 12.7 cm) with Cellsorb bedding, at an ambient temperature of 21 ± 1°C and lights on from 22:00 to 10:00 hours. Mice had ad lib access to food, and water access restricted to 2 hours per day, immediately after testing. Mice were transported in a light shielded transporter to the testing room; the mice were tested between 11:00 and 16:00 hours, and were always tested in the dark.
