replicated across GWAS, the specific SNPs identified may be different 18. To address this challenge, we developed a 3-stage approach to review GWAS results and select specific SNPs to include in a GRS. We devised our approach to be systematic and replicable and to leverage the discovery potential of GWAS while minimizing risk for including false-positive markers. In this article, we describe this 3-stage approach, apply it to develop a GRS for obesity, and test the GRS as a measure of obesity risk using data from the population-based Atherosclerosis Risk in the Communities (ARIC) Study.
