Elevated oxidative stress and extra-mitochondrial oxygen consumption are also speculated to contribute to SZ.28 Cell-to-cell variability in transcription has been well recognized in microbial cells, particularly in cellular stress-responsive genes,29 and elevated cell-to-cell transcriptional variability in aged cardiomyocytes occurs as a result of increased genome damage by oxidative injury.30 The mechanisms producing higher variability in the HSF1 activation in SZ hiPSC NPCs requires further investigation.
