We observed one linkage peak that satisfied empirical genomewide significance criteria (i.e., based on simulations); this corresponded to a maximum lod score of 3.32 on chromosome 10 at 117.4 cM (10q23.3–q24.1) (genomewide empirical p=0.033; point p=0.00005) (Figure 1). The location and the value of this peak did not change when analyses were repeated using different r2 values for grouping SNPs into clusters. The 95% (i.e., one LOD-unit) confidence interval is a 10 cM region between 115.1 cM and 125.3 cM. Lod scores greater than 1 were also observed on chromosome 9 (lod score 1.01 at 66.4 cM); chromosome 14 (a lod score of 1.03 at 32.0 cM); chromosome 16 (lod score 1.2 at 29.9 cM); and chromosome 17 (lod score 1.67 at 48.9 cM). Notably, no lod score >0.33 was observed on chromosome 4, which is the chromosome where positive linkage signals have been observed most consistently in other (i.e., non-AA) populations (6–8, 10, 11).
