The results presented here must be considered in light of our methods. The caveats include the fact the subjects were all well educated White males, half of whom had a family history of AUDs. Thus, the generalizability of the current results to other population groups needs to be established. It is also important to note that the SRE questionnaire had not been developed until these subjects were in their mid thirties, and it will be useful to evaluate how the SRE performs in similar analyses when the form is filled out by younger subjects followed over several decades. In these analyses the SRE scores were corrected for outliers, and only subjects with clearly low and high LR scores were used in some analyses, so it is well to keep in mind that selecting subjects at the extremes of the scores has the potential of inflating correlations. In addition, the low LR is only one of several alcohol reaction measures, and there are other important phenotypes regarding future alcohol problems that were not studied here, including those that relate to impulsivity and associated characteristics, and preexisting psychiatric disorders (Newlin and Renton, 2010; Schuckit, 2009; Yip et al., 2012).
