Chunk #60 — Methods — MAGMA primary and conditional analyses

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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.

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MAGMA can also perform conditional analyses given its linear regression framework. We used MAGMA to test whether cell types were associated with a specific trait conditioning on the gene-level genetic association of another trait (Z-value from MAGMA .out file) or to look for associations of cell types conditioning on the 10% most specific genes from other cell types by adding these variables as covariate in the model.