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Chunk #14 — Results — Effects of Childhood Disorders on Subsequent Substance Use Disorders — Childhood ADHD and Conduct Disorder-- Effects on SUD Outcome

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Psychopathology in offspring from families of alcohol dependent female probands: a prospective study.
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A series of Cox Regression analyses were performed to determine the effect of particular childhood disorders on outcome (Tables 4a, 4b, 4c). The presence of an externalizing disorder in childhood was an antecedent predictor of subsequent Alcohol Abuse or Dependence, Drug Abuse or Dependence, or presence of either (SUD) based on data collected at an average follow up interval of 5.04 ± 4.12 years. The presence of childhood ADHD significantly decreased survival time for Alcohol Abuse or Dependence, Drug Abuse or Dependence, or SUD by young adulthood. Analyses performed controlling for the gender of the offspring did not alter this relationship between ADHD and SUD (Wald = 20.30, df =1, p = <0.001) indicating that both girls and boys with ADHD were more likely to develop SUD.