Examining transcriptional changes in the nucleus accumbens from cocaine abusers identified decreased expression of myelin transcripts for a majority of cases as well as changes in transcripts encoding proteins associated with cytoskeletal and synaptic functions.19 Transcriptional changes in postmortem dorsolateral prefrontal cortex from cocaine abusers indicated altered neural plasticity, oligodendrocyte function, cytoskeleton and related signaling, oxidative phosphorylation, energy metabolism and mitochondrial function.21
