The current study examines genome-wide associations with PTSD in the Collaborative Study on the Genetics of Alcoholism (COGA), a study of families many of which are densely affected with alcohol use disorders. Primary analyses will examine the relation of recent GWAS of PTSD [9, 22] to PTSD, alcohol dependence, and other substance dependence diagnoses, including cannabis, cocaine, and opioid dependence in the COGA sample, and how these associations may differ between males and females. Exploratory analyses will examine relations between PTSD PRS and PTSD and other substance dependence diagnoses in individuals with and without alcohol dependence.
