2016; Tucker and others 2014]. To understand better the mechanisms that link ADH1B and ALDH2 with the predisposition to cancer, different authors have investigated the genomic features of AAC tissue. Both the ADH1B and ALDH2 genes showed downregulation in different types of tumor tissues [Kropotova and others 2014; Liu and others 2015] and this seems to be due to epigenetic changes, such as hypermethylation of the promoter regions and non-hystonic acetylation [Shen and others 2016; Udali and others 2015].
