As yet, there is limited CNV evidence implicating specific genes or genomic regions in bipolar disorder. Likewise, pathway enrichment analyses have not shown clear patterns. Pathway enrichment analyses of CNV in Zhang et al reported enrichment of genes associated with psychological disorders and genes involved in learning (Zhang et al., 2009a). We examined pathways enriched among de novo CNVs in bipolar disorder and observed an enrichment of genes involved in regulation of cell shape, but we did not observe a significant enrichment of genes involved in neuronal function or development (Malhotra et al., 2011).
