Two participants had one ADH1B*2 allele, rare in samples of African ancestry. Seven participants were heterozygous for ALDH1A*2 (ALDH1A*1/*2) and four were heterozygous for ALDH1A*3 (ALDH1A*1/*3). ADH1B*2 has been shown to influence alcohol response (Cook et al., 2005; Duranceaux et al., 2006), while the influence of ALDH1A*2 and ALDH1A*3 alleles on response to alcohol is uncertain. Participants with these alleles (n = 13) were excluded from study analyses testing the effect of ADH1B and ADH1C on alcohol response1.
