intake and contributes to the enhancement of drug-seeking induced response-contingent pavlovian cues after overtraining.30 Similarly, the dorsal striatum regulates habitual31 and punishmentresistant32 drug-seeking behaviors that emerge after extensive exposure to the drug. This suggests that ventral portions of the striatum control the acute reinforcing properties of addictive drugs, whereas dorsal striatum regulates the habit-like consumption that defines addiction. Understanding these mechanisms by which cocaine rewires the striatum to drive compulsive-like drug-seeking responses may reveal novel treatment strategies for drug addiction.
