In contrast, available annotations suggest that the 16p13 region contains only two genes of unknown function, KIAA0350 and dexamethasone-induced transcript (Fig. 5). Also, the region of association identified on 18p11 (Supplementary Fig. 14), which seems to confer susceptibility to all three autoimmune conditions studied (combined trend test P=9×10-8, P=4.6×10-8 for CD, 1.9×10-2 for RA, and 1.9×10-6 for T1D: Supplementary Table 11), maps to a single gene, PTPN2 (protein tyrosine phosphatase, non-receptor type 2), a member of the same family as PTPN22 and PTPN11 and involved in immune regulation96.
