Since subject inclusion and recruitment criteria vary widely among genetic association studies we carried out further analyses to examine the effects of the inclusion criteria on the significance of the observed genetic associations. Figure 2 clearly shows that p-values are different within different subsets of the sample. In some cases, the more stringent inclusion criteria yielded stronger genetic associations, whereas in other cases association was most significant in the whole sample. This set of analyses was done last and conducted separately to examine the patterns of p-values across inclusion criteria. Individual p-values from these plots are not adjusted for multiple testing, because the goal was to examine the pattern, not to extract genetic significance of a single SNP.
